- Age-related macular degeneration is a premature aging of the retina.
- Several factors come into play in this multifactorial disease, including those with an inflammatory effect, as well as the genetic background.
- Blue-violet light is mainly responsible for the process of apoptosis as it causes a photochemical phenomenon that leads to the overloading of retinal pigment epithelium cells with an extremely toxic component, named lipofuscin.
- We can try to reduce the apoptotic process by adopting a combined approach.
- Large steps have been taken to demonstrate the negative effect of blue-violet light on retinal cells in the macula and thus on the retinal pigment epithelium and photoreceptors.
- Studies have evidenced that light wavelengths from 415 to 455 nanometers are particularly harmful.
Professor Giuseppe Querques is Associate Professor and Head of Medical Retina & Imaging Unit at University Vita-Salute, Milan, Italy.